The 80% SSRI Occupancy Finding: Signal or Shortcut?
How did a brain-imaging result become both a dosing benchmark and an argument about antidepressant withdrawal? The frequently repeated SSRI SERT occupancy finding comes from a landmark 2004 PET study. It reported that commonly used minimum therapeutic doses occupied...
What a Medication Review Should Reconstruct
A psychiatric medication review can become a very small conversation: Are you doing okay? Any side effects? Need a refill? That may be enough to keep a prescription moving. It is rarely enough to determine whether the medication still makes sense. A February 2026...